Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

BACKGROUND: The tandem of P domains in a weak inward rectifying K+ channel (TWIK)‐related acid‐sensitive K(+) channel (TASK‐1; hK (2P)3.1) two‐pore–domain potassium channel was recently shown to regulate the atrial action potential duration. In the human heart, TASK‐1 channels are specifically expre...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Wiedmann, Felix, Beyersdorf, Christoph, Zhou, Xiaobo, Büscher, Antonius, Kraft, Manuel, Nietfeld, Jendrik, Walz, Teo Puig, Unger, Laura A., Loewe, Axel, Schmack, Bastian, Ruhparwar, Arjang, Karck, Matthias, Thomas, Dierk, Borggrefe, Martin, Seemann, Gunnar, Katus, Hugo A., Schmidt, Constanze
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660874/
https://ncbi.nlm.nih.gov/pubmed/32390491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015751
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