The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model

BACKGROUND: Upregulation of the two-pore-domain potassium channel TASK-1 (hK(2)(P)3.1) was recently described in patients suffering from atrial fibrillation (AF) and resulted in shortening of the atrial action potential. In the human heart, TASK-1 channels facilitate repolarization and are specifica...

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Dettagli Bibliografici
Pubblicato in:Front Physiol
Autori principali: Wiedmann, Felix, Beyersdorf, Christoph, Zhou, Xiao-Bo, Kraft, Manuel, Foerster, Kathrin I., El-Battrawy, Ibrahim, Lang, Siegfried, Borggrefe, Martin, Haefeli, Walter E., Frey, Norbert, Schmidt, Constanze
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858671/
https://ncbi.nlm.nih.gov/pubmed/33551849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.629421
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