Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils

[Image: see text] A BF(3)·OEt(2) catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycle...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Adolfsson, Dan E., Tyagi, Mohit, Singh, Pardeep, Deuschmann, Adrian, Ådén, Jörgen, Gharibyan, Anna L., Jayaweera, Sanduni Wasana, Lindgren, Anders E. G., Olofsson, Anders, Almqvist, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660745/
https://ncbi.nlm.nih.gov/pubmed/33099999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c01699
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