Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers

[Image: see text] Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is an established tool in drug development, which enables visualization of drugs and drug metabolites at spatial localizations in tissue sections from different organs. However, robust and accurate qu...

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Publicado en:Anal Chem
Autores principales: Källback, Patrik, Vallianatou, Theodosia, Nilsson, Anna, Shariatgorji, Reza, Schintu, Nicoletta, Pereira, Marcela, Barré, Florian, Wadensten, Henrik, Svenningsson, Per, Andrén, Per E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660593/
https://ncbi.nlm.nih.gov/pubmed/33086792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c03203
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