Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation

The cellular origin of sporadic pancreatic neuroendocrine tumors (PNETs) is obscure. Hormone expression suggests that these tumors arise from glucagon-producing alpha cells or insulin-producing β cells, but instability in hormone expression prevents linage determination. We utilize loss of hepatic g...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Smith, Derek K., Kates, Lance, Durinck, Steffen, Patel, Nisha, Stawiski, Eric W., Kljavin, Noelyn, Foreman, Oded, Sipos, Bence, Solloway, Mark J., Allan, Bernard B., Peterson, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659536/
https://ncbi.nlm.nih.gov/pubmed/33205067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100058
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