Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells

Gemtuzumab ozogamicin (GO) consists of the CD33 antibody linked to calicheamicin. The binding of GO to the CD33 antigen on leukemic cells results in internalization followed by the release of calicheamicin, thereby inducing DNA strand breaks. We hypothesized that the induction of DNA strand breaks w...

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Bibliografische gegevens
Gepubliceerd in:Cancer Sci
Hoofdauteurs: Yamauchi, Takahiro, Matsuda, Yasufumi, Tasaki, Toshiki, Negoro, Eiju, Ikegaya, Satoshi, Takagi, Kazutaka, Yoshida, Akira, Urasaki, Yoshimasa, Ueda, Takanori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2012
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659370/
https://ncbi.nlm.nih.gov/pubmed/22632031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02343.x
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