Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells

Gemtuzumab ozogamicin (GO) consists of the CD33 antibody linked to calicheamicin. The binding of GO to the CD33 antigen on leukemic cells results in internalization followed by the release of calicheamicin, thereby inducing DNA strand breaks. We hypothesized that the induction of DNA strand breaks w...

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Vydáno v:Cancer Sci
Hlavní autoři: Yamauchi, Takahiro, Matsuda, Yasufumi, Tasaki, Toshiki, Negoro, Eiju, Ikegaya, Satoshi, Takagi, Kazutaka, Yoshida, Akira, Urasaki, Yoshimasa, Ueda, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2012
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659370/
https://ncbi.nlm.nih.gov/pubmed/22632031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02343.x
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