Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells

Gemtuzumab ozogamicin (GO) consists of the CD33 antibody linked to calicheamicin. The binding of GO to the CD33 antigen on leukemic cells results in internalization followed by the release of calicheamicin, thereby inducing DNA strand breaks. We hypothesized that the induction of DNA strand breaks w...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Yamauchi, Takahiro, Matsuda, Yasufumi, Tasaki, Toshiki, Negoro, Eiju, Ikegaya, Satoshi, Takagi, Kazutaka, Yoshida, Akira, Urasaki, Yoshimasa, Ueda, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659370/
https://ncbi.nlm.nih.gov/pubmed/22632031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02343.x
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