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Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer

Intratumoral delivery of drug-encoding plasmid DNA (pDNA) enables localised in vivo expression of biological drugs, offering an attractive alternative to conventional protein treatment. However, this requires physical or chemical methods to enhance the low transfection efficiency of naked pDNA. Elec...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Jacobs, Liesl, De Smidt, Elien, Geukens, Nick, Declerck, Paul, Hollevoet, Kevin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659317/
https://ncbi.nlm.nih.gov/pubmed/33177564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75206-2
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