Chimeric anti‐podoplanin antibody suppresses tumor metastasis through neutralization and antibody‐dependent cellular cytotoxicity

Podoplanin is a platelet aggregation‐inducing factor associated with tumor metastasis, malignant progression, and cancer stem cells. We produced a rat–human chimeric anti‐podoplanin mAb, NZ‐8, from rat anti‐podoplanin mAb (NZ‐1). Although both NZ‐1 and NZ‐8 possess high binding affinities and high n...

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Publicado en:Cancer Sci
Autores principales: Kaneko, Mika Kato, Kunita, Akiko, Abe, Shinji, Tsujimoto, Yuta, Fukayama, Masashi, Goto, Kaoru, Sawa, Yoshihiko, Nishioka, Yasuhiko, Kato, Yukinari
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2012
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659283/
https://ncbi.nlm.nih.gov/pubmed/22816430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02385.x
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