Iron facilitator LS081 reduces hypoxia‐inducible factor‐1α protein and functions as anticancer agent in hepatocellular carcinoma

Hypoxia inducible factor‐1α (HIF‐1α) has a central role in cellular oxygen‐sensing, and its overexpression in many types of cancer is considered important in tumor progression. Thus, targeting HIF‐1α production and activity has been of great therapeutic interest. In normoxic conditions, HIF‐1α is hy...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Tanaka, Hiroki, Li, Zhen, Ikuta, Katsuya, Addo, Lynda, Akutsu, Hiroaki, Nakamura, Masao, Sasaki, Katsunori, Ohtake, Takaaki, Fujiya, Mikihiro, Torimoto, Yoshihiro, Glass, Jonathan, Kohgo, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2012
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659231/
https://ncbi.nlm.nih.gov/pubmed/22181812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2011.02192.x
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