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SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions

Intratumoral hypoxic cells are more resistant to radiotherapy due to a reduction in lifespan of DNA‐damaging free radicals and augmentation of post‐irradiation molecular restoration. SirT1, a member of the mammalian sirtuin family, deacetylates various transcription factors to trigger cell defense a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Sci
Main Authors: Xie, Yuexia, Zhang, Jianghong, Ye, Shuang, He, Mingyuan, Ren, Ruiping, Yuan, Dexiao, Shao, Chunlin
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659182/
https://ncbi.nlm.nih.gov/pubmed/22448750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02285.x
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