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SirT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
Intratumoral hypoxic cells are more resistant to radiotherapy due to a reduction in lifespan of DNA‐damaging free radicals and augmentation of post‐irradiation molecular restoration. SirT1, a member of the mammalian sirtuin family, deacetylates various transcription factors to trigger cell defense a...
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| Publicado no: | Cancer Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7659182/ https://ncbi.nlm.nih.gov/pubmed/22448750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02285.x |
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