Differentially Methylated Regions in Desmoid-Type Fibromatosis: A Comparison Between CTNNB1 S45F and T41A Tumors

INTRODUCTION: The majority of desmoid-type fibromatosis (DTF) tumors harbor a β-catenin mutation, affecting specific codons in CTNNB1 exon 3. S45F tumors are reported to have a higher chance of recurrence after surgery and more resistance to systemic treatments compared to wild-type (WT) and T41A tu...

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Pubblicato in:Front Oncol
Autori principali: Timbergen, Milea J. M., Boers, Ruben, Vriends, Anne L. M., Boers, Joachim, van IJcken, Wilfred F. J., Lavrijsen, Marla, Grünhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Smits, Ron, Gribnau, Joost, Wiemer, Erik A. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658920/
https://ncbi.nlm.nih.gov/pubmed/33194643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.565031
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