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Noncompetitive allosteric antagonism of death receptor 5 by a synthetic affibody ligand
Fatty acid-induced upregulation of death receptor 5 (DR5) and its cognate ligand, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), promotes hepatocyte lipoapoptosis, which is a key mechanism in the progression of fatty liver disease. Accordingly, inhibition of DR5 signaling represent...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biochemistry |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7658720/ https://ncbi.nlm.nih.gov/pubmed/32941010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00529 |
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