miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro

We investigated whether microRNA-150 (miR-150)-based RNA interference (RNAi) ameliorates tubular injury and tubulointerstitial fibrosis. Mice injected with folic acid developed tubulointerstitial fibrosis at day 30. miR-150 levels were increased at day 7 and peaked at day 30. At day 30, protein leve...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Luan, Junjun, Fu, Jingqi, Wang, Dongdong, Jiao, Congcong, Cui, Xiangfei, Chen, Chengjie, Liu, Dan, Zhang, Yixiao, Wang, Yanqiu, Yuen, Peter S.T., Kopp, Jeffrey B., Pi, Jingbo, Zhou, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658580/
https://ncbi.nlm.nih.gov/pubmed/33230482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.008
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