FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells

RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering RNA (siRNA) and shows great promise in delineating gene functions and in developing therapeutics for human diseases. However, effective gene silencing usually requires the delivery of multiple siRNAs for a given gene,...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: He, Fang, Ni, Na, Zeng, Zongyue, Wu, Di, Feng, Yixiao, Li, Alexander J., Luu, Benjamin, Li, Alissa F., Qin, Kevin, Wang, Eric, Wang, Xi, Wu, Xiaoxing, Luo, Huaxiu, Zhang, Jing, Zhang, Meng, Mao, Yukun, Pakvasa, Mikhail, Wagstaff, William, Zhang, Yongtao, Niu, Changchun, Wang, Hao, Huang, Linjuan, Shi, Deyao, Liu, Qing, Zhao, Xia, Fu, Kai, Reid, Russell R., Wolf, Jennifer Moriatis, Lee, Michael J., Hynes, Kelly, Strelzow, Jason, El Dafrawy, Mostafa, Gan, Hua, He, Tong-Chuan, Fan, Jiaming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658575/
https://ncbi.nlm.nih.gov/pubmed/33230483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.007
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