FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells

RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering RNA (siRNA) and shows great promise in delineating gene functions and in developing therapeutics for human diseases. However, effective gene silencing usually requires the delivery of multiple siRNAs for a given gene,...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: He, Fang, Ni, Na, Zeng, Zongyue, Wu, Di, Feng, Yixiao, Li, Alexander J., Luu, Benjamin, Li, Alissa F., Qin, Kevin, Wang, Eric, Wang, Xi, Wu, Xiaoxing, Luo, Huaxiu, Zhang, Jing, Zhang, Meng, Mao, Yukun, Pakvasa, Mikhail, Wagstaff, William, Zhang, Yongtao, Niu, Changchun, Wang, Hao, Huang, Linjuan, Shi, Deyao, Liu, Qing, Zhao, Xia, Fu, Kai, Reid, Russell R., Wolf, Jennifer Moriatis, Lee, Michael J., Hynes, Kelly, Strelzow, Jason, El Dafrawy, Mostafa, Gan, Hua, He, Tong-Chuan, Fan, Jiaming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658575/
https://ncbi.nlm.nih.gov/pubmed/33230483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.10.007
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