A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

BACKGROUND: Metformin is a widely prescribed antidiabetic BCS Class III drug (low permeability) that depends on active transport for its absorption and disposition. It is recommended by the US Food and Drug Administration as a clinical substrate of organic cation transporter 2/multidrug and toxin ex...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Hanke, Nina, Türk, Denise, Selzer, Dominik, Ishiguro, Naoki, Ebner, Thomas, Wiebe, Sabrina, Müller, Fabian, Stopfer, Peter, Nock, Valerie, Lehr, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658088/
https://ncbi.nlm.nih.gov/pubmed/32449077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00896-w
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