Site-Specific Radioiodination of an Anti-HER2 Single Domain Antibody Fragment with a Residualizing Prosthetic Agent

INTRODUCTION: As a consequence of their small size, high stability and high affinity, single domain antibody fragments (sdAb) are appealing targeting vectors for radiopharmaceutical development. With sdAbs binding to internalizing receptors like HER2, residualizing prosthetic agents can enhance tumo...

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Published in:Nucl Med Biol
Main Authors: Feng, Yutian, Zhou, Zhengyuan, McDougald, Darryl, Meshaw, Rebecca L., Vaidyanathan, Ganesan, Zalutsky, Michael R.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657985/
https://ncbi.nlm.nih.gov/pubmed/32448731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2020.05.002
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