Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation

PURPOSE: Our previous studies with F-18-labeled anti-HER2 single-domain antibodies (sdAbs) utilized 5F7, which binds to the same epitope on HER2 as trastuzumab, complicating its use for positron emission tomography (PET) imaging of patients undergoing trastuzumab therapy. On the other hand, sdAb 2Rs...

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Detalhes bibliográficos
Publicado no:Mol Imaging Biol
Main Authors: Zhou, Zhengyuan, Vaidyanathan, Ganesan, McDougald, Darryl, Kang, Choong Mo, Balyasnikova, Irina, Devoogdt, Nick, Ta, Angeline N., McNaughton, Brian R., Zalutsky, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662479/
https://ncbi.nlm.nih.gov/pubmed/28409338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-017-1082-x
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