Functional analysis of a species-specific inhibitor selective for human Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY)

The Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes. As citrate is a key metabolite and regulator of multiple biochemical pathways, deletion of Slc13a5 in mice protects against diet-induced obesity, diabetes, and metabolic syndrome...

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Vydáno v:Biochem J
Hlavní autoři: Higuchi, Kei, Kopel, Jonathan J., Sivaprakasam, Sathish, Jaramillo-Martinez, Valeria, Sutton, R. Bryan, Urbatsch, Ina L., Ganapathy, Vadivel
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2020
Témata:
Cell Membranes, Excitation & Transport
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657661/
https://ncbi.nlm.nih.gov/pubmed/33079129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200592
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