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5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts

BACKGROUND: All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated isocitrate dehydrogenase and dihydroorotate dehydrogenase (DHODH) has revived...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Dembitz, Vilma, Lalic, Hrvoje, Kodvanj, Ivan, Tomic, Barbara, Batinic, Josip, Dubravcic, Klara, Batinic, Drago, Bedalov, Antonio, Visnjic, Dora
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657321/
https://ncbi.nlm.nih.gov/pubmed/33176741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07533-6
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