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Cell of origin in radiation‐induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele
Bcl11b is a haploinsufficient tumor suppressor, mutations or deletion of which has been found in 10–16% of T‐cell acute lymphoblastic leukemias. Bcl11b(KO) (/+) heterozygous mice are susceptible to thymic lymphomas, a model of T‐cell acute lymphoblastic leukemia, when γ‐irradiated, and irradiated Bc...
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| Publicado no: | Cancer Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7657184/ https://ncbi.nlm.nih.gov/pubmed/23663453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12193 |
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