Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features

BRG1 and BRM, two core catalytic subunits in SWI/SNF chromatin remodeling complexes, have been suggested as tumor suppressors, yet their roles in carcinogenesis are unclear. Here, we present evidence that loss of BRG1 and BRM is involved in the progression of lung adenocarcinomas. Analysis of 15 lun...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Matsubara, Daisuke, Kishaba, Yuka, Ishikawa, Shumpei, Sakatani, Takashi, Oguni, Sachiko, Tamura, Tomoko, Hoshino, Hiroko, Sugiyama, Yukihiko, Endo, Shunsuke, Murakami, Yoshinori, Aburatani, Hiroyuki, Fukayama, Masashi, Niki, Toshiro
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7657156/
https://ncbi.nlm.nih.gov/pubmed/23163725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12065
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