Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures

Decreased cell-substratum adhesion is crucially involved in metastasis. Previous studies demonstrated that lung cancer with floating cell clusters in histology is more likely to develop metastasis. In the present study, we investigated whether cancer cells in long-term, three-dimensional low attachm...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nakano, Tomoyuki, Kanai, Yoshihiko, Amano, Yusuke, Yoshimoto, Taichiro, Matsubara, Daisuke, Shibano, Tomoki, Tamura, Tomoko, Oguni, Sachiko, Katashiba, Shizuka, Ito, Takeshi, Murakami, Yoshinori, Fukayama, Masashi, Murakami, Takashi, Endo, Shunsuke, Niki, Toshiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546599/
https://ncbi.nlm.nih.gov/pubmed/28786996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181342
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