CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients

BACKGROUND: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice. However, the significance of CYP27A1 expression on BC biology and prognosis is...

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Bibliografski detalji
Izdano u:Breast Cancer Res
Glavni autori: Kimbung, Siker, Inasu, Maria, Stålhammar, Tor, Nodin, Björn, Elebro, Karin, Tryggvadottir, Helga, Ygland Rödström, Maria, Jirström, Karin, Isaksson, Karolin, Jernström, Helena, Borgquist, Signe
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656740/
https://ncbi.nlm.nih.gov/pubmed/33176848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01347-x
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