Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project

BACKGROUND: Genome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the MTHFR co-factor) can lower blood pressure (BP) in hypertensiv...

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Publicado en:BMC Med
Main Authors: Ward, Mary, Hughes, Catherine F., Strain, J. J., Reilly, Rosie, Cunningham, Conal, Molloy, Anne M., Horigan, Geraldine, Casey, Miriam, McCarroll, Kevin, O’Kane, Maurice, Gibney, Michael J., Flynn, Albert, Walton, Janette, McNulty, Breige A., McCann, Adrian, Kirwan, Laura, Scott, John M., McNulty, Helene
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656675/
https://ncbi.nlm.nih.gov/pubmed/33172445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-020-01780-x
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