Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood vessels that regulates blood-cell traffic as well as the maintenance and function of haematopoietic stem and progenitor cells. Here, we report the design and in vivo performance of systemically injected lipid...

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Publicado no:Nat Biomed Eng
Main Authors: Krohn-Grimberghe, Marvin, Mitchell, Michael J., Schloss, Maximilian J., Khan, Omar F., Courties, Gabriel, Guimaraes, Pedro P.G., Rohde, David, Cremer, Sebastian, Kowalski, Piotr S., Sun, Yuan, Tan, Mingchee, Webster, Jamie, Wang, Karin, Iwamoto, Yoshiko, Schmidt, Stephen P., Wojtkiewicz, Gregory R., Nayar, Ribhu, Frodermann, Vanessa, Hulsmans, Maarten, Chung, Amanda, Hoyer, Friedrich Felix, Swirski, Filip K., Langer, Robert, Anderson, Daniel G., Nahrendorf, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655681/
https://ncbi.nlm.nih.gov/pubmed/33020600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-00623-7
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