Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood vessels that regulates blood-cell traffic as well as the maintenance and function of haematopoietic stem and progenitor cells. Here, we report the design and in vivo performance of systemically injected lipid...

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Vydáno v:Nat Biomed Eng
Hlavní autoři: Krohn-Grimberghe, Marvin, Mitchell, Michael J., Schloss, Maximilian J., Khan, Omar F., Courties, Gabriel, Guimaraes, Pedro P.G., Rohde, David, Cremer, Sebastian, Kowalski, Piotr S., Sun, Yuan, Tan, Mingchee, Webster, Jamie, Wang, Karin, Iwamoto, Yoshiko, Schmidt, Stephen P., Wojtkiewicz, Gregory R., Nayar, Ribhu, Frodermann, Vanessa, Hulsmans, Maarten, Chung, Amanda, Hoyer, Friedrich Felix, Swirski, Filip K., Langer, Robert, Anderson, Daniel G., Nahrendorf, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655681/
https://ncbi.nlm.nih.gov/pubmed/33020600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-00623-7
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