Impact of a Gap Junction Protein Alpha 4 Variant on Clinical Disease Phenotype in F508del Homozygous Patients With Cystic Fibrosis

BACKGROUND: Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junc...

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Dettagli Bibliografici
Pubblicato in:Front Genet
Autori principali: Horn, Tabea, Ludwig, Michael, Eickmeier, Olaf, Neerinex, Anne H., Maitland-van der Zee, Anke H., Smaczny, Christina, Wagner, Thomas O. F., Schubert, Ralf, Zielen, Stefan, Majoor, Christof, Bos, Lieuwe D., Schmitt-Grohé, Sabina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Genetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655539/
https://ncbi.nlm.nih.gov/pubmed/33193670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.570403
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