Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle

Foxg1 plays important roles in regeneration of hair cell (HC) in the cochlea of neonatal mouse. Here, we used Sox9-CreER to knock down Foxg1 in supporting cells (SCs) in the utricle in order to investigate the role of Foxg1 in HC regeneration in the utricle. We found Sox9 an ideal marker of utricle...

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Bibliografske podrobnosti
izdano v:Aging (Albany NY)
Main Authors: Zhang, Yuan, Zhang, Shasha, Zhang, Zhonghong, Dong, Ying, Ma, Xiangyu, Qiang, Ruiying, Chen, Yin, Gao, Xia, Zhao, Chunjie, Chen, Fangyi, He, Shuangba, Chai, Renjie
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals 2020
Teme:
Priority Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655167/
https://ncbi.nlm.nih.gov/pubmed/33099273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.104009
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