Synthesis, trehalase hydrolytic resistance and inhibition properties of 4- and 6-substituted trehalose derivatives

Although trehalose has recently gained interest because of its pharmaceutical potential, its clinical use is hampered due to its low bioavailability. Hence, hydrolysis-resistant trehalose analogues retaining biological activity could be of interest. In this study, 34 4- and 6-O-substituted trehalose...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Dhaene, Shari, Van der Eycken, Johan, Beerens, Koen, Franceus, Jorick, Desmet, Tom, Caroen, Jurgen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655077/
https://ncbi.nlm.nih.gov/pubmed/33164573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1837125
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