Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells

BACKGROUND: Both humoral and cellular immune mechanisms are involved in the onset and progression of autoimmune responses in systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of SLE via the dysregulation of type I interferon (IFN) product...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Shigesaka, Minoru, Ito, Tomoki, Inaba, Muneo, Imai, Kai, Yamanaka, Hideki, Azuma, Yoshiko, Tanaka, Akihiro, Amuro, Hideki, Nishizawa, Tohru, Son, Yonsu, Satake, Atsushi, Ozaki, Yoshio, Nomura, Shosaku
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654586/
https://ncbi.nlm.nih.gov/pubmed/33168076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-02356-z
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