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Bis(benzoyl) phosphate inactivators of beta-lactamase C from Mtb

The class A β-lactamase BlaC is a cell surface expressed serine hydrolase of Mycobacterium tuberculosis (Mtb), one of the causative agents for Tuberculosis in humans. Mtb has demonstrated increased susceptibility to β-lactam antibiotics upon inactivation of BlaC; thus, making BlaC a rational enzyme...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: White, Dawanna S., Choy, Cindy J., Moural, Timothy W., Martin, Stacy E., Wang, Jing, Gargaro, Samantha, Kang, ChulHee, Berkman, Clifford E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654513/
https://ncbi.nlm.nih.gov/pubmed/31281019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.07.002
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