Reovirus σ1 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment

Reovirus attachment protein σ1 is a trimeric molecule containing tail, body, and head domains. During infection, σ1 engages sialylated glycans and junctional adhesion molecule-A (JAM-A), triggering uptake into the endocytic compartment, where virions are proteolytically converted to infectious subvi...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Diller, Julia R., Halloran, Sean R., Koehler, Melanie, dos Santos Natividade, Rita, Alsteens, David, Stehle, Thilo, Dermody, Terence S., Ogden, Kristen M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Structure and Assembly
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654274/
https://ncbi.nlm.nih.gov/pubmed/32938765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01163-20
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