Generation of Genetically RGD σ1-Modified Oncolytic Reovirus That Enhances JAM-A-Independent Infection of Tumor Cells

Mammalian reovirus (MRV) strain type 3 Dearing (T3D) is a naturally occurring oncolytic virus that has been developed as a potential cancer therapeutic. However, MRV treatment cannot be applied to cancer cells expressing low levels of junctional adhesion molecule A (JAM-A), which is the entry recept...

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Библиографические подробности
Опубликовано в: :J Virol
Главные авторы: Kawagishi, Takahiro, Kanai, Yuta, Nouda, Ryotaro, Fukui, Ichika, Nurdin, Jeffery A., Matsuura, Yoshiharu, Kobayashi, Takeshi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Virus-Cell Interactions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654265/
https://ncbi.nlm.nih.gov/pubmed/32907973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01703-20
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