Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor‐mutated lung cancer model

Non‐small‐cell lung cancers with epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs); however, unlike cytotoxic agents, it is generally accepted that minimal doses of drugs inhibiting target molecules are sufficient when molecular‐targeted agents...

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Vydáno v:Cancer Sci
Hlavní autoři: Hayakawa, Hiromi, Ichihara, Eiki, Ohashi, Kadoaki, Ninomiya, Takashi, Yasugi, Masayuki, Takata, Saburo, Sakai, Katsuya, Matsumoto, Kunio, Takigawa, Nagio, Tanimoto, Mitsune, Kiura, Katsuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2013
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654246/
https://ncbi.nlm.nih.gov/pubmed/24033722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12284
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