Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor‐mutated lung cancer model

Non‐small‐cell lung cancers with epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs); however, unlike cytotoxic agents, it is generally accepted that minimal doses of drugs inhibiting target molecules are sufficient when molecular‐targeted agents...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hayakawa, Hiromi, Ichihara, Eiki, Ohashi, Kadoaki, Ninomiya, Takashi, Yasugi, Masayuki, Takata, Saburo, Sakai, Katsuya, Matsumoto, Kunio, Takigawa, Nagio, Tanimoto, Mitsune, Kiura, Katsuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654246/
https://ncbi.nlm.nih.gov/pubmed/24033722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12284
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