Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor‐mutated lung cancer model

Non‐small‐cell lung cancers with epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs); however, unlike cytotoxic agents, it is generally accepted that minimal doses of drugs inhibiting target molecules are sufficient when molecular‐targeted agents...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Hayakawa, Hiromi, Ichihara, Eiki, Ohashi, Kadoaki, Ninomiya, Takashi, Yasugi, Masayuki, Takata, Saburo, Sakai, Katsuya, Matsumoto, Kunio, Takigawa, Nagio, Tanimoto, Mitsune, Kiura, Katsuyuki
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654246/
https://ncbi.nlm.nih.gov/pubmed/24033722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12284
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