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Memory-assisted reinforcement learning for diverse molecular de novo design

In de novo molecular design, recurrent neural networks (RNN) have been shown to be effective methods for sampling and generating novel chemical structures. Using a technique called reinforcement learning (RL), an RNN can be tuned to target a particular section of chemical space with optimized desira...

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Détails bibliographiques
Publié dans:J Cheminform
Auteurs principaux: Blaschke, Thomas, Engkvist, Ola, Bajorath, Jürgen, Chen, Hongming
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654024/
https://ncbi.nlm.nih.gov/pubmed/33292554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-020-00473-0
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