Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs

BACKGROUND: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. However, the mechanism by which morphine causes these effects and how the...

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Dades bibliogràfiques
Publicat a:Clin Epigenetics
Autors principals: Muñoa-Hoyos, Iraia, Halsall, John A., Araolaza, Manu, Ward, Carl, Garcia, Idoia, Urizar-Arenaza, Itziar, Gianzo, Marta, Garcia, Paloma, Turner, Bryan, Subirán, Nerea
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654014/
https://ncbi.nlm.nih.gov/pubmed/33168052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00955-w
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