Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs

BACKGROUND: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. However, the mechanism by which morphine causes these effects and how the...

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Detalles Bibliográficos
Publicado en:Clin Epigenetics
Main Authors: Muñoa-Hoyos, Iraia, Halsall, John A., Araolaza, Manu, Ward, Carl, Garcia, Idoia, Urizar-Arenaza, Itziar, Gianzo, Marta, Garcia, Paloma, Turner, Bryan, Subirán, Nerea
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654014/
https://ncbi.nlm.nih.gov/pubmed/33168052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00955-w
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