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Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H(2)O(2)) that is expressed in various epithelial cells and in macrophages. Here, we developed an anti-AQP3 monoclonal antibody (mAb) that inhibited AQP3-facilitated H(2)O(2) and glycerol transport, and prevented liver inj...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7653938/ https://ncbi.nlm.nih.gov/pubmed/33168815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19491-5 |
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