Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase‐deficient mice

Succinic semialdehyde dehydrogenase deficiency (SSADHD) manifests with low levels of glutamine in the brain, suggesting that central glutamine deficiency contributes to pathogenesis. Recently, we attempted to rescue the disease phenotype of aldh5a1 (−/−) mice, a murine model of SSADHD with dietary g...

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Publicado en:JIMD Rep
Autores principales: Brown, Madalyn N., Gibson, K. Michael, Schmidt, Michelle A., Walters, Dana C., Arning, Erland, Bottiglieri, Teodoro, Roullet, Jean‐Baptiste
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653255/
https://ncbi.nlm.nih.gov/pubmed/33204597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmd2.12151
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