Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells

BACKGROUND: Tyrosine kinase inhibitor (TKI) resistance is a major obstacle in treatment of non-small cell lung cancer (NSCLC). MET amplification drives resistance to EGFR-TKIs in 5–20% of initially sensitive EGFR: mutated NSCLC patients, and combined treatment with EGFR-TKIs and MET-TKIs can overcom...

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Detalhes bibliográficos
Publicado no:Transl Lung Cancer Res
Main Authors: Clement, Michelle Simone, Gammelgaard, Kristine Raaby, Nielsen, Anders Lade, Sorensen, Boe Sandahl
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7653150/
https://ncbi.nlm.nih.gov/pubmed/33209611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr-20-522
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