MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine

This study investigated the effect of methyl-CpG-binding protein 2 (MeCP2) on miRNA transcription. Our results of miRNA chip assay and ChIP-seq showed that MeCP2 inhibited the expressions of numerous miRNAs by binding to their upstream elements, including not only the promoter but also the distal en...

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Pubblicato in:Oncogenesis
Autori principali: Tong, Dongdong, Zhang, Jing, Wang, Xiaofei, Li, Qian, Liu, Liying, Lu, Axin, Guo, Bo, Yang, Juan, Ni, Lei, Qin, Hao, Zhao, Lingyu, Huang, Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652948/
https://ncbi.nlm.nih.gov/pubmed/33168819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00281-z
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