EZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c

EZH2, a histone methyltransferase, has been shown to involve in cancer development and progression via epigenetic regulation of tumor suppressor microRNAs, whereas BMI1, a driver of hepatocellular carcinoma (HCC), is a downstream target of these microRNAs. However, it remains unclear whether EZH2 ca...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Xu, Leibo, Lin, Junlong, Deng, Wanyu, Luo, Weixin, Huang, Yipei, Liu, Chao-Qun, Zhang, Fa-Peng, Qin, Yu-Fei, Wong, Ping-Pui, Liu, Chao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652937/
https://ncbi.nlm.nih.gov/pubmed/33168810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00284-w
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