Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation

Hereditary Spastic Paraplegia (HSP) is a neurodegenerative disease most commonly caused by autosomal dominant mutations in the SPG4 gene encoding the microtubule-severing protein spastin. We hypothesise that SPG4-HSP is attributable to reduced spastin function because of haploinsufficiency; thus, th...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Sardina, Francesca, Pisciottani, Alessandra, Ferrara, Manuela, Valente, Davide, Casella, Marialuisa, Crescenzi, Marco, Peschiaroli, Angelo, Casali, Carlo, Soddu, Silvia, Grierson, Andrew J, Rinaldo, Cinzia
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7652396/
https://ncbi.nlm.nih.gov/pubmed/33106322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000799
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