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Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
In mechanosensory hair cells (HCs) of the ear, the transcriptional repressor REST is continuously inactivated by alternative splicing of its pre-mRNA. This mechanism of REST inactivation is crucial for hearing in humans and mice. Rest is one of many pre-mRNAs whose alternative splicing is regulated...
Gorde:
| Argitaratua izan da: | Life Sci Alliance |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Life Science Alliance LLC
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7652395/ https://ncbi.nlm.nih.gov/pubmed/33087486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000841 |
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