TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

PURPOSE: The tripartite motif-containing family member TRIM37 is involved in a number of important biological and pathological processes, and it has recently been shown to be an essential regulator of protein ubiquitination and a contributor to tumorigenesis. We previously showed that TRIM37 is over...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Chen, Shiyu, He, Zhiwei, Zhu, Changhao, Liu, Yanqing, Li, Lin, Deng, Lu, Wang, Jun, Yu, Chao, Sun, Chengyi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651862/
https://ncbi.nlm.nih.gov/pubmed/33194618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.554787
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