DDRE-29. SMOOTHENED-ACTIVATING LIPIDS DRIVE RESISTANCE TO CDK4/6 INHIBITION IN HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA

BACKGROUND: Medulloblastoma is an aggressive pediatric brain tumor that is associated with misactivation of the Hedgehog (HH) pathway. Our lab has shown that CDK6, a critical activator of the cell cycle, is a direct transcriptional target of oncogenic HH signaling, and that inhibiting CDK6 blocks th...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Daggubati, Vikas, Hochstelter, Jordan, Bommireddy, Ani, Choudhury, Abrar, Krup, Alexis, Kaur, Pervinder, Tong, Pakteema, Li, Amy, Xu, Libin, Reiter, Jeremy, Raleigh, David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Drug Discovery, Drug Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651735/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.274
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