EXTH-15. INHIBITION OF 2-HG LEADS TO UPREGULATION OF A PRO-INFLAMMATORY GENE SIGNATURE IN A NOVEL HLA-A2/HLA-DR1 TRANSGENIC MOUSE MODEL OF IDH1(R132H)-EXPRESSING GLIOMA

Recent studies have demonstrated the impacts of 2-HG on the anti-tumor immune response in isocitrate dehydrogenase (IDH)-mutant gliomas. Our laboratory has reported that mutant IDH1 (IDH1(R132H)) suppresses STAT1, the master regulator of IFN-responses and IFN-inducible chemokines, thereby contributi...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Chuntova, Polly, Nicolay, Brandon, Hudson, Christine, Narayanaswamy, Rohini, Ronseaux, Sebastien, Montoya, Megan, Downey, Kira, Okada, Hideho
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Preclinical Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651622/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.369
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